Is your open-innovation successful? The mediating role of a firm's organizational and social context

Open firms are not equally successful. This is because, in order to benefit from external sources of knowledge, firms must be able to absorb such knowledge. The paper outlines a firm’s context as a set of organizational and social features, which may be considered absorptive capacity antecedents. It explores the mediating role of such antecedents in the relationship – hitherto insufficiently researched – between the degree of openness and innovative performance. The use of a methodology combining both direct interviews and survey of Italian firms has allowed us to confirm the supposed mediating role. We also identify different modes for companies to open up their innovation process and, for each of them, the antecedents that are consistent with choices regarding the degree of openness

Listen to my breath: Exploring expressive function of breathing sounds in imitation and emotional attunement

Diversi studi hanno dimostrato i reciproci rapporti di influenza tra respiro e variabili psicologiche ma scarsa attenzione è stata rivolta all’indagine delle funzioni espressive del suono del respiro. Studio 1 è stato finalizzato alla costruzione di un modello di analisi multi-livello per la descrizione acustica del respiro. Sono state effettuate audio e video registrazioni del respiro di 2 coppie di soggetti in performance individuali e congiunte. Sui 1903 respiri raccolti sono state condotte analisi video e audio che hanno portato alla costruzione di tre categorie di indici: respiratori, acustici e interattivi (relativi alla relazione tra i comportamenti respiratori di due partners in un’azione congiunta). Studio 2 ha investigato cosa poteva essere inferito dall’ascolto del suono respiro relativamente all’identità, allo stato emotivo e all’attività svolta da una persona. Inoltre, ha verificato se l’imitazione facilitasse l’identificazione rispetto al solo ascolto. Sono state raccolte registrazioni ecologiche del respiro di persone coinvolte in 6 attività e 4 emozioni. Un campione di 90 persone ha ascoltato le tracce e risposto ad un questionario relativo alle suddette variabili. Altre 90 persone prima di rispondere imitavano il respiro. Il campione ha efficacemente inferito informazioni relative alle variabili indagate, con risultati migliori nel task di imitazione. Studio 3 mirava a descrivere acusticamente 6 condizioni di respiro emotivo (rabbia, paura, tristezza, disgusto, tenerezza, gioia) e a investigare se “respirare insieme” influenzasse il processo di sintonizzazione. 20 coppie di donne hanno partecipato. Per ogni emozione, entro ogni coppia una partecipante leggeva una storia emotivamente connotata e respirava come se si trovasse in quella situazione. L’altra esprimeva la propria vicinanza respirando come lei. Al termine rispondevano a un questionario. I respiri sono stati audio registrati e analizzati. E’ stato possibile ricondurre ciascuna delle emozioni a un differente pattern respiratorio. Inoltre il task ha influenzato diverse dimensioni della sintonizzazione: la sincronizzazione, il decoding emotivo, l’esperienza emotiva e la percezione di somiglianza interpersonale.Several psycho-physiological studies have provided evidences about the reciprocal influence between respiration and psychological variables but few attentions have been brought to the investigation of the expressive function of breathing sounds. Study 1 aims to build a multilayer analysis model that enable an acoustic description of breathing sounds. Audio and video recordings of breathing of two pairs of participants engaged in individual and joint performance were conducted. 1903 were video and audio analyzed and 3 sets of indexes were derived: respiratory, acoustic and interactive (aimed to relate partner’s respiratory behaviour during joint performances). Study 2 investigates what could be inferred about a person’s identity, emotional state and activity from the sound of his/her breathing. Moreover, it aims to verify whether imitation of breathing patterns improve the identification of those features. Ecological recordings of breathing sounds of people engaged in 6 activities and 4 emotions. 90 participants listen to the tracks and answer a questionnaire about such variables. Other 90 mimicked the tracks before answering. Participants were able to infer valuable information about the aspects under investigation with better results in the imitation task. Study 3 aims to describe the acoustic features of 6 emotional breathing patterns (anger, fear, sadness, disgust, tenderness and joy) and to see whether breathing together could strengthen the attunement process. 20 pairs of women participated. For each emotion, within the pair one participant read a story emotionally connoted and breathes as if she actually was in that situation. Her partner had to convey her closeness breathing in the same way. Finally they filled in a questionnaire. Different respiratory patterns were related to each emotion. Moreover the task influenced several attunement dimensions: synchronization, emotional decoding, emotional experience and perception of interpersonal similarity

Listening to and mimicking respiration: Understanding and synchronizing joint actions

Several studies provided evidence about the mutual influence between respiration and performance: breathing influences and is in turn influenced both by motor (Raßler & Kohl, 2000) and mental processes (Wientjes, Grossman, & Gaillard, 1998). Field experiences suggest that participants engaged in joint performances requiring a high degree of synchronization tend to breathe together to manage precise temporal coordination. This paper presents two studies aimed to explore if breathing sounds convey information about the activity being performed and to describe interpersonal breathing coordination during a joint action. In Study 1, 180 participants listened to ecological tracks of breathing sounds related to six activities different in degree of mental and physical effort in two conditions: listening vs. imitation. Most demanding activities were identified the most. Imitation significantly improved identification accuracy. Study 2 was aimed to develop a multilayer analysis to relate partners’ respiratory behaviour during joint actions and to describe their respiratory and acoustic features. Audio recording of breathing sounds of a dyad was taken during a baseline and a joint obstacle course, both video-recorded. Respiratory, acoustic, and coordination indices were extracted and related to six action units. The multilayer analysis provided quantitative measurements of respiratory behaviour that enable descriptions and comparisons between conditions and actions

Technological Strategy, Open Innovation and Performance: Evidences by a Structural- Equation-Model Approach

Purpose – The purpose of this study is to shed further light on determinants of the openness degree to give a more conclusive evidence to the research in the field. In particular, the influence exerted by the technological strategy is still debated, in that evidence on the relationship between the technological strategy and openness is conflicting. Design/methodology/approach – The authors put forward a structural equation model which enriches the state-of-the-art literature by explicitly testing the interplay among technological strategy, openness (innovatively measured in terms of partner intensity, phase intensity and variety in terms of partners, phases and contents) and innovation performance. Our study relies on data from 415 firms based on a research survey developed in Finland, Italy and Sweden. Findings – Findings show that openness, if measured in terms of partner intensity and phase intensity, fully mediates the relationship between technological strategy and innovation performance, by suggesting that the effectiveness of a firm’s technologically aggressive behavior is strongly related to the intensification of collaboration with the partners along the innovation funnel. Conversely, openness variety seems to play an opposite role and is influenced differently by partner and phase intensity. This result likely emphasizes how the cost-side of open behavior becomes harder to manage, and thus costly, when it involves too many different types of partners, phases and contents. Practical implications – Firms that adopt a technologically aggressive strategy are recommended to deeply open their innovation process to foster innovation performance. However, because of the fact that a high level of openness variety could generate some drawbacks, managers should be very careful in the management of different phases, sources and content. Therefore, what clearly emerges is a call to find adequate strategies for effectively managing the collaboration process to avoid the waste of resources and initiatives. Originality/value – Originality and the value of the paper reside in a more fine-grained definition of the openness concept, which takes into consideration other facets of openness compared to those usually analyzed in the literature, and a powerful statistical model, such as structural equation modeling, offering great advantages and flexibility in matching the theoretical model with the data

Homogeneous Open Quantum Random Walks on a lattice

We study Open Quantum Random Walks for which the underlying graph is a lattice, and the generators of the walk are translation-invariant. We consider the quantum trajectory associated with the OQRW, which is described by a position process and a state process. We obtain a central limit theorem and a large deviation principle for the position process, and an ergodic result for the state process. We study in detail the case of homogeneous OQRWs on a lattice, with internal space $h={\mathbb C}^2$

Post hoc analysis of a randomized, double-blind, prospective trial evaluating a CXCR1/2 inhibitor in new-onset type 1 diabetes: endo-metabolic features at baseline identify a subgroup of responders

AimIn a recent randomized, multicenter trial (NCT02814838) a short-term anti-inflammatory treatment with ladarixin (LDX; an inhibitor of the CXCR1/2 chemokine receptors) did not show benefit on preserving residual beta cell function in new-onset type 1 diabetes. We present a post hoc analysis of trial patients in the predefined subgroup analysis developed according to baseline daily insulin requirement (DIR) tertiles.MethodA double-blind, randomized (2:1), placebo-controlled study was conducted in 45 men and 31 women (aged 18–46 years) within 100 days of the first insulin administration. Patients received LDX (400 mg twice daily) for three cycles of 14 days on/14 days off, or placebo. The primary endpoint was the area under the curve for C-peptide [AUC (0–120 min)] in response to a 2-h mixed meal tolerance test (MMTT) at week 13 ± 1. Seventy-five patients completed the week 13 MMTT and were divided into three groups according to the DIR tertiles: lower, ≤ 0.23U/kg/die (n = 25); middle, 0.24–0.40 U/kg/die (n = 24); upper, ≥ 0.41 U/kg/die (n = 26).ResultsWhen considering the patients in the upper tertile (HIGH-DIR), C-peptide AUC (0–120 min) at 13 weeks was higher in the LDX group (n = 16) than in the placebo (n = 10) group [difference: 0.72 nmol/L (95% CI 0.9–1.34), p = 0.027]. This difference reduced over time (0.71 nmol/L at 26 weeks, p = 0.04; 0.42 nmol/L at 52 weeks, p = 0.29), while it has never been significant at any time in patients in the lower and/or middle tertile (LOW-DIR). We characterized at baseline the HIGH-DIR and found that endo-metabolic (HOMA-B, adiponectin, and glucagon-to-C-peptide ratio) and immunologic (chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemoattractant protein 1 (MCP1) and Vascular Endothelial Growth Factor (VEGF)) features distinguished this group from LOW-DIR.ConclusionWhile LDX did not prevent the progressive loss of beta-cell function in the majority of treated subjects, the post hoc analysis suggests that it could work in subjects with HIGH-DIR at baseline. As we found differences in endo-metabolic and immunologic parameters within this subgroup, this generates the hypothesis that the interactions between host factors and drug action can contribute to its efficacy. Further research is needed to evaluate this hypothesis

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription